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Featured Publications
"Control of feeding behavior by cerebral ventricular volume transmission of melanin-concentrating hormone"

Noble EE, Hahn JD, Konanur VR, Hsu TM, Page SJ, Cortella AM, Liu CM, Song MY, Suarez AN, Szujewski CC, Rider D, Clarke JE, Darvas M, Appleyard SM, Kanoski SE (Cell Metabolism. 2018; 28(1): 55-68)

Traditional textbook knowledge indicates that the cerebral spinal fluid (CSF) acts primarily as [1] a buffer/barrier protecting the brain from mechanical impact with the skull, and/or [2] a medium for flushing metabolic waste from the brain’s cellular tissue. Here we show that the CSF is an active pathway for biological communication by providing evidence for CSF-mediated “volume transmission” of melanin-concentrating hormone (MCH) in the control of feeding behavior. These findings suggest that humoral-like signaling of neuropeptides in the cerebral ventricles may be a common biological pathway in the control of fundamental behaviors.
"Gut vagal sensory signaling regulates hippocampus function through multi-order pathways"

Suarez AN, Hsu TM, Liu CM, Noble EE, Cortella AM, Nakamoto EM, Hahn JD, de Lartigue G, Kanoski SE (Nature Communications. 2018; 9(1): 2181)

Using a novel surgical approach and various rodent behavioral procedures, our results reveal that gastrointestinal-derived sensory signaling from the vagus nerve (the 10th cranial nerve) plays a physiological role in hippocampal-dependent learning and memory function. To determine the neural pathways connecting the gut to the hippocampus, our approach utilized monosynaptic and multisynaptic virus-based tracing methods to identify the medial septum as a relay connecting the caudal brainstem to glutamatergic neurons in the dorsal hippocampus. Overall these findings identify a novel role for the gut-brain axis in the control of learning and memory.
"A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling."

Hsu TM, Noble EE, Liu CM, Cortella AM, Konanur VR, Suarez AN, Reiner DJ, Hahn JD, Hayes MR, Kanoski SE (Molecular Psychiatry. 2018; Epub ahead of print)

Using viral-mediated RNA-interference, this manuscript reveals that glucagon-like peptide-1 receptor (GLP-1R) signaling in the ventral hippocampus (pyramidal CA1 region) functions under normal conditions to reduce meal size and motivated responding for palatable food. Reversible chemogenetic-mediated synaptic silencing of monosynaptic input from ventral CA1 to medial prefrontal cortex (infralimbic and prelimbic regions) NDMA receptors eliminated the anorectic effects of ventral CA1 GLP-1R activation. Overall these findings identify a novel neural pathway that inhibits motivated and impulsive responding for “junk food”.
"Early life sugar consumption affects the rat microbiome independent of obesity."

Noble EE, Hsu TM, Jones RB, Fodor AA, Goran MI, Kanoski SE (The Journal of Nutrition. 2017 Jan; 147(1): 20-28)

The impact of dietary factors on the gut microbiome, recently identified as a critical regulator of mammalian health and disease, is poorly understood. Here we show in rats that sugar-sweetened beverage consumption during the juvenile and adolescent period drastically alters the gut microbiome, with ~25% of all gut bacterial families significantly impacted relative to controls. These effects were not dependent on monosaccharide ratio, nor were they associated with changes in anthropometric measures and total caloric intake. Ongoing follow-up work is examining whether these gut microbiome changes are causally related to sugar-induced memory dysfunction.
"Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways."

Hsu TM, Hahn JD, Konanur VR, Noble EE, Suarez AN, Thai J, Nakamoto EM, Kanoski SE (eLife. Dec 15, 2015; 4: e11190)

Most animals, including humans, have habitual feeding patterns in which meals are consumed based on learned and/or environmental factors. In this paper we unravel the neural circuitry mediating this type of conditioned feeding behavior. Our data show that ghrelin, a gut-derived hormone, signals to neurons in the hippocampus (ventral CA1) to promote meal-entrained conditioned appetite. We next reveal that the appetite-promoting effects of ventral hippocampus ghrelin signaling involve downstream communication with neurons in the lateral hypothalamus that produce the neuropeptide, orexin.
Peer-Reviewed Journal Publications:



2018 Publications (* = corresponding author)
Control of feeding behavior by cerebral ventricular volume transmission of melanin-concentrating hormone Noble EE, Hahn JD, Konanur VR, Hsu TM, Page SJ, Cortella AM, Liu CM, Song MY, Suarez AN, Szujewski CC, Rider D, Clarke JE, Darvas M, Appleyard AM, *Kanoski SE (2018). Cell Metabolism, 28(1): 55-68. [Paper featured on Cell Metabolism cover art and highlighted in Nature Reviews Endocrinology and by the F1000].
Gut vagal sensory signaling regulates hippocampus function through multi-order pathways Suarez AN, Hsu TM, Liu CM, Noble EE, Cortella AM, Nakamoto EM, Hahn JD, *de Lartigue G, *Kanoski SE (2018). Nature Communications, 9(1): 2181. [Paper in the top 2% of all scientific outputs of a similar age rated by Altmetric].
Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity Lee SJ, Sanchez-Watts G, Krieger J, Pignalosa A, Norell P, Corella AM, Pettersen K, Vrdoljak D, Hayes MR, Kanoski SE, *Langhans W, *Watts AG (2018). Molecular Metabolism (Epub ahead of print).
Homeostatic and non-homeostatic controls of feeding behavior: distinct vs. common neural substrates Liu CM, *Kanoski SE (2018). Physiology and Behavior (Epub ahead of print).
Hippocampus ghrelin receptor signaling promotes socially-mediated learned food preference Hsu TM, Noble EE, Reiner DJ, Liu CM, Suarez AN, Konanur VR, Hayes MR, *Kanoski SE (2018). Neuropharmacology, 131: 487-496.
Early life sugar consumption has long-term negative effects on memory function in male rats Noble EE, Hsu TM, Liang J, *Kanoski SE (2018). Nutritional Neuroscience (Epub ahead of print).
Glucagon-like peptide-1 receptor signaling in the lateral dorsal tegmental nucleus regulates energy balance Reiner DJ, Leon R, McGrath LE, Koch-Laskowski K, Hahn JD, Kanoski SE, Mietlicki-Baase EG, *Hayes MR (2018). Neuropsychopharmacology, 43(3): 627-637.
Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight Lopez-Ferraras L, Richard JE, Noble EE, Eerola K, Anderberg RH, Taing L., Kanoski SE, Hayes MR, *Skibicka KP (2018). Molecular Psychiatry (Epub ahead of print).
A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling Hsu TM, Noble EE, Liu CM, Cortella AM, Konanur VR, Suarez AN, Reiner DJ, Hahn JD, Hayes MR, *Kanoski SE (2018). Molecular Psychiatry (Epub ahead of print).
2017 Publications
Ghrelin's control of food reward and body weight in the lateral hypothalamic area is sexually dimorphic Lopez-Ferrars L, Richard JE, Anderberg RH, Nilsson FH, Olandersson K, Kanoski SE, *Skibicka KP (2017). Physiology and Behavior; 176 (40-49).
Early life sugar consumption affects the rat microbiome independent of obesity Noble EE, Hsu TM, Jones RB, Fodor AA, Goran MI, *Kanoski SE (2017). The Journal of Nutrition; 147(1): 20-28.
Gut to brain dysbiosis: Mechanisms linking Western Diet consumption, the microbiome, and cognitive impairment Noble EE, Hsu TM, *Kanoski SE (2017). Frontiers in Behavioral Neuroscience; 11 (1-10). [Paper in the top 2% of all scientific outputs of a similar age rated by Altmetric].
Amylin acts in the lateral dorsal tegmental nucleus to regulate energy balance through GABA signaling Reiner DJ, Mietlicki-Baase EG, Olivos DR, McGrath LE, Zimmer DJ, Kock-Laskowski K, Krawczyk J, Turner C, Noble EE, Hahn JD, Schmidt HD, Kanoski SE, *Hayes MR (2017). Biological Psychiatry; 82(11): 828-838.
Hippocampus contributions to food intake control: mnemonic, neuroanatomical, and endocrine mechanisms *Kanoski SE, Grill HJ (2017). Biological Psychiatry; 81(9): 748-756. [Paper selected by F1000].
2016 Publications
Ghrelin: A link between memory and ingestive behavior Hsu TM, Suarez AN, *Kanoski SE (2016). Physiology and Behavior; 162: 10-17.
GLP-1 and weight loss: unraveling the diverse neural circuitry *Kanoski SE, Hayes MR, Skibicka SP (2016). American Journal of Physiology: Regulatory, Integrative and Comparative Physiology; 310(10): R885-95.
Astrocytes regulate GLP-1 receptor-mediated effects on energy balance Reiner DJ, Mietlicki-Baase EG, McGrath LE, Zimmer DJ, Bence KK, Sousa GL, Konanur VR, Krawczyk J, Burk DH, Kanoski SE, Hermann GE, Rodgers RC, *Hayes MR (2016). Journal of Neuroscience; 36(12): 3531-40.
Early life exposure to obesogenic diets and learning and memory dysfunction Noble EE, *Kanoski SE (2016). Current Opinion in Behavioral Sciences; 9: 7-14.
Hindbrain GLP-1 receptor mediation of cisplatin-induced anorexia and nausea *De Jonghe BC, Holland R, Olivos DR, Rupprecht LE, Kanoski SE, Hayes MR (2016). Physiology and Behavior; 153: 109-14.
2015 PUBLICATIONS
Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways Hsu TM, Hahn JD, Konanur VR, Noble EE, Suarez AN, Thai J, Nakamoto EM, *Kanoski SE. (2015). eLife; 2015; 4: e1110.
Liraglutide, leptin, and their combined effects on feeding: additive intake reduction through common intracellular signaling mechanisms *Kanoski SE, Ong ZY, Fortin SM, Schlessinger ES, Grill HJ (2015). Diabetes, Obesity and Metabolism; 17(3): 285-93.
Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats Hsu TM, Konanur VR, Taing L, Usui R, Kayser BD, Goran MI, *Kanoski SE (2015). Hippocampus; 25(2): 227-39.
Hippocampal GLP-1 receptors influence food intake, meal size, and effort-based responding for food through volume transmission Hsu TM, Hahn JD, Konanur VR, Lam A, *Kanoski SE (2015). Neuropsychopharmacology; 40(2): 327-37.
2014 PUBLICATIONS
Protein Tyrosine Phosphatase 1B is a Novel Regulator of Central Brain-Derived Neurotrophic Factor and Tropomyosin Receptor Kinase B Signaling Ozek C, Kanoski SE, Zhang ZY, Grill HJ, *Bence KK (2014). Journal of Biological Chemistry; 289(46): 31682-92
Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia Hsu TM, *Kanoski SE (2014). Frontiers in Aging Neuroscience; 6:88
Incretins and Amylin: Neuroendocrine Communication Between the Gut, Pancreas, and Brain in Control of Food Intake and Blood Glucose *Hayes MR, Mietlicki-Baase EG, Kanoski SE, De Jonghe BC (2014). Annual Review of Nutrition; 34: 237-60.
Leptin signaling in the medial nucleus tractus solitarius reduces food seeking and willingness to work for food *Kanoski SE, Alhadeff AL, Fortin SM, Gilbert JR, Grill HJ (2014). Neuropsychopharmacology; 39(3): 605-13.
2013 PUBLICATIONS
Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling. *Kanoski SE, Fortin SM, Ricks KM, Grill HJ (2013). Biological Psychiatry; 73(9): 915-23
2012 PUBLICATIONS (Prior to Kanoski lab at USC)
Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner. Zhao S, Kanoski SE, Yan J, *Grill HJ, *Hayes MR (2012). International Journal of Obesity; 36(12): 1522-8.
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. De Jonghe BC, Hayes MR, Zimmer DJ, Kanoski SE, Grill HJ, *Bence KK (2012). American Journal of Physiology: Endocrinology and Metabolism; 303(5): E644-51
Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. Kanoski SE, Zhao S, Guarnieri DJ, DiLeone RJ, Yan J, De Jonghe BC, Bence KK, Hayes MR, *Grill HJ (2012). American Journal of Physiology: Endocrinology and Metabolism; 303(4): E496-503
Cognitive and neuronal systems underlying obesity *Kanoski SE (2012). Physiology and Behavior; 106(3): 337-44
TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin. Spaeth AM, Kanoski SE, Hayes MR, *Grill HJ (2012). American Journal of Physiology: Endocrinology and Metabolism; 302(10): E1252-60.
The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide. Kanoski SE, Rupprecht LE, Fortin SM, De Jonghe BC, *Hayes MR (2012). Neuropharmacology; 62(5-6): 1916-27
2011 PUBLICATIONS
Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. McKay NJ, Kanoski SE, Hayes MR, *Daniels D (2011). American Journal of Physiology: Regulatory, Integrative and Comparative Physiology; 301(6): R1755-64.
The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. Hayes MR, Kanoski SE, De Jonghe BC, Leichner TM, Alhadeff AL, Fortin SM, Arnold M, Langhans W, *Grill HJ (2011). American Journal of Physiology: Regulatory, Integrative and Comparative Physiology; 301(5): R1479-85.
Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. *Kanoski SE, Fortin SM, Arnold M, Grill HJ, Hayes MR (2011). Endocrinology; 152(8): 3103-12.
Hippocampal leptin signaling reduces food intake and modulates food-related memory processing. *Kanoski SE, Hayes MR, Greenwald HS, Fortin SM, Gianessi CA, Gilbert JR, Grill HJ (2011). Neuropsychopharmacology; 36(9): 1859-70
Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats. *Hayes MR, *Kanoski SE, Alhadeff AL, Grill HJ (2011). Obesity; 19(7): 1342-9.
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, *Bence KK (2011). American Journal of Physiology: Endocrinology and Metabolism; 300(6): E1002-11.
Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Kanoski SE, *Davidson TL (2011). Physiology and Behavior; 103(1): 59-68.
Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Hayes MR, Leichner TM, Zhao S, Lee GS, Chowansky A, Zimmer D, De Jonghe BC, Kanoski SE, *Grill HJ, *Bence KK (2011). Cell Metabolism; 13(3): 320-30.
2010 PUBLICATIONS
Role of the glucagon-like-peptide-1 receptor in the control of energy balance. *Hayes MR, De Jonghe BC, Kanoski SE (2010). Physiology and Behavior; 100(5): 503-10.
Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet. *Kanoski SE, Davidson TL (2010). Journal of Experimental Psychology: Animal Behavior Processes; 36(2): 313-9
Hippocampal lesions impair retention of discriminative responding based on energy state cues. *Davidson TL, Kanoski SE, Chan K, Clegg DJ, Benoit SC, Jarrard LE (2010). Behavioral Neuroscience; 124(1): 97-105.
The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. *Kanoski SE, Zhang Y, Zheng W, Davidson TL (2010). Journal of Alzheimer's Disease; 21(1): 207-19.
2005-2009 PUBLICATIONS
Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation. *Davidson TL, Chan K, Jarrard LE, Kanoski SE, Clegg DJ, Benoit SC (2009). Hippocampus; 19(3): 235-52
A potential role for the hippocampus in energy intake and body weight regulation. *Davidson TL, Kanoski SE, Schier LA, Clegg DJ, Benoit SC (2007). Current Opinion in Pharmacology; 7(6): 613-6
The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Kanoski SE, Meisel RL, Mullins AJ, *Davidson TL (2007). Behavioural Brain Research; 182(1): 57-66.
Interoceptive "satiety" signals produced by leptin and CCK. Kanoski SE, Walls EK, *Davidson TL (2007). Peptides; 28(5): 988-1002
Memory inhibition and energy regulation. *Davidson TL, Kanoski SE, Walls EK, Jarrard LE (2005). Physiology and Behavior; 86(5): 731-46
The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation. *Davidson TL, Kanoski SE, Tracy AL, Walls EK, Clegg D, Benoit SC (2005). Peptides. 2005; 26(9): 1602-10.